Statins

Statins are a class of medications commonly used to help lower cholesterol levels, particularly low-density lipoprotein (LDL) cholesterol, as part of cardiovascular risk management.

• Statins belong to a class of lipid-lowering medications.
• They are among the most widely studied medications for cardiovascular risk reduction.

• Lowering LDL cholesterol.
• Reducing cardiovascular risk in people with elevated risk.
• Secondary prevention in people with a history of cardiovascular events.

• Statins work by inhibiting an enzyme involved in cholesterol synthesis in the liver (HMG-CoA reductase).
• This typically leads to reduced LDL cholesterol production and increased clearance from the bloodstream.

• Muscle aches or discomfort are among the most commonly discussed side effects.
• Digestive symptoms and changes in liver enzyme tests are also reported.
• Most people tolerate statins without side effects, but any new symptoms should be discussed with a clinician.

• Rare but serious muscle-related effects have been reported.
• Liver function is typically monitored during treatment.
• Use during pregnancy and breastfeeding is generally avoided.
• These warnings are educational and not exhaustive; always consult a healthcare professional.

• Certain other medications, including some antibiotics and antifungals, can interact with statins.
• Grapefruit juice may affect some statins.
• Discuss all medications and supplements with a clinician or pharmacist.

• What time of day should I take this medication?
• What side effects should prompt me to call my clinician?
• Are there foods or other medications I should avoid?
• How will my response be monitored?